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Article

Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.

Addiction (Abingdon, England) - 1 May 2014

Culverhouse Robert C, Johnson Eric O, Breslau Naomi, Hatsukami Dorothy K, Sadler Brooke, Brooks Andrew I, Hesselbrock Victor M, Schuckit Marc A, Tischfield Jay A, Goate Alison M, Saccone Nancy L, Bierut Laura J

Abstract excerpt

AIMS: Studies have shown association between common variants in the α6-β3 nicotinic receptor subunit gene cluster and nicotine dependence in European ancestry populations. We investigate whether this generalizes to African Americans, whether the association is specific to nicotine dependence and whether this region contains additional genetic contributors to nicotine dependence. DESIGN: We examined consistency of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24401102
DOI: 10.1111/add.12478
PMCID: PMC3984604

Genes

CHRNB3
CHRNA6

Provenance

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