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Article

Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.

Scientific reports - 28 Mar 2014

Sadler Brooke, Haller Gabe, Agrawal Arpana, Culverhouse Rob, Bucholz Kathleen, Brooks Andy, Tischfield Jay, Johnson Eric O, Edenberg Howard, Schuckit Marc, Saccone Nancy, Bierut Laura, Goate Alison

Abstract excerpt

In the U.S.A., cocaine is the second most abused illicit drug. Variants within the CHRNB3-A6 gene cluster have been associated with cigarette consumption in several GWAS. These receptors represent intriguing candidates for the study of cocaine dependence because nicotinic receptors are thought to be involved in generalized addiction pathways. Using genotypic data from a GWAS of the Study of Addiction: Genetics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24675634
DOI: 10.1038/srep04497
PMCID: PMC4894386

Genes

CHRNB3
CHRNA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.PMID 24675634Read ↗

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