Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

doi:10.1038/mp.2008.42

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Article

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.

Molecular psychiatry - 1 May 2009

Wang J C, Grucza R, Cruchaga C, Hinrichs A L, Bertelsen S, Budde J P, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, Rice J P, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg H J, Bierut L J, Goate A M

Abstract excerpt

Alcohol dependence frequently co-occurs with cigarette smoking, another common addictive behavior. Evidence from genetic studies demonstrates that alcohol dependence and smoking cluster in families and have shared genetic vulnerability. Recently a candidate gene study in nicotine dependent cases and nondependent smoking controls reported strong associations between a missense mutation (rs16969968) in exon 5 of...

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Identifiers

PMID: 18414406
DOI: 10.1038/mp.2008.42
PMCID: PMC4381434

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence.PMID 18414406Read ↗

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