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Article

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2010

Sherva Richard, Kranzler Henry R, Yu Yi, Logue Mark W, Poling James, Arias Albert J, Anton Raymond F, Oslin David, Farrer Lindsay A, Gelernter Joel

Abstract excerpt

There is shared genetic risk for dependence on multiple substances, and the nicotinic receptor gene cluster on chromosome 15 harbors multiple polymorphisms that associate to this risk. Here, we report the results of an association study with 21 SNPs genotyped across the CHRNA5, CHRNA3, and CHRNB4 loci on chromosome 15q25.1. The sample consists of a discovery set (N=1858) of European-American and African-American...

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Source

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Identifiers

PMID: 20485328
DOI: 10.1038/npp.2010.64
PMCID: PMC3055642

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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