Article
DNA damage-activated ABL-MyoD signaling contributes to DNA repair in skeletal myoblasts.
Cell death and differentiation - 1 Dec 2013
Simonatto M, Marullo F, Chiacchiera F, Musaró A, Wang J Y J, Latella L, Puri P L
Abstract excerpt
Previous works have established a unique function of MyoD in the control of muscle gene expression during DNA damage response in myoblasts. Phosphorylation by DNA damage-activated ABL tyrosine kinase transiently inhibits MyoD-dependent activation of transcription in response to genotoxic stress. We show here that ABL-MyoD signaling is also an essential component of the DNA repair machinery in myoblasts exposed to...
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