Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells.

Cancer research - 1 May 2009

Mannefeld Mirijam, Klassen Elena, Gaubatz Stefan

Abstract excerpt

In response to DNA damage, several signaling pathways that arrest the cell cycle in G(1) and G(2) are activated. The down-regulation of mitotic genes contributes to the stable maintenance of the G(2) arrest. The human LINC or DREAM complex, together with the B-MYB transcription factor, plays an essential role in the expression of G(2)-M genes. Here, we show that DNA damage results in the p53-dependent binding of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to DNA Damage
Share to Doxorubicin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G2 Phase

Share to HCT116 Cells

Share to Repressor Proteins

Share to Trans-Activators

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 19383908
DOI: 10.1158/0008-5472.CAN-08-4156

Genes

MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-MYB is required for recovery from the DNA damage-induced G2 checkpoint in p53 mutant cells.PMID 19383908Read ↗

Myb-Binding Protein 1A (MYBBP1A) Is Essential for Early Embryonic Development, Controls Cell Cycle and Mitosis, and Acts as a Tumor SuppressorSemantic proximity Read ↗

Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling.Semantic proximity Read ↗

LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G<sub>2</sub>/M GenesSemantic proximity Read ↗

RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activationSemantic proximity Read ↗

The cell cycle gene regulatory DREAM complex is disrupted by high expression of oncogenic B-MybSemantic proximity Read ↗

Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability.Semantic proximity Read ↗

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYBSemantic proximity Read ↗

c-Myb Contributes to G 2 /M Cell Cycle Transition in Human Hematopoietic Cells by Direct Regulation of Cyclin B1 ExpressionSemantic proximity Read ↗

Analyzing the G2/M checkpoint.Semantic proximity Read ↗

DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activationSemantic proximity Read ↗

B-Myb protein in cellular proliferation, transcription control, and cancer: Latest developmentsSemantic proximity Read ↗

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.