Article

Ataxia Telangiectasia and Rad3-related protein (ATR) maintains cardiac tissue functionality

2020-01-01

Abstract excerpt

To counteract DNA damage, cells have evolved several mechanisms collectively termed as the DNA damage response (DDR). A key member of DDR signaling in mammalian cells is ATR (Ataxia Telangiectasia and Rad3-related protein), a PIKK kinase that is activated by single-strand DNA lesions in response to replication stress. Severe ATR deficiency owing to hypomorphic germline mutations in ATR causes the Seckel syndrome,...

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Literature Corpus work: 124025f9-660c-5b5f-b5a3-2d29ebc10628
DOI: 10.21954/ou.ro.00011e53

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