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Article

Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo.

PloS one - 1 Jan 2009

Lagirand-Cantaloube Julie, Cornille Karen, Csibi Alfredo, Batonnet-Pichon Sabrina, Leibovitch Marie Pierre, Leibovitch Serge A

Abstract excerpt

Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known. The transcription factor MyoD controls myogenic stem cell function and differentiation, and seems necessary to maintain the differentiated phenotype of adult fast skeletal muscle fibres. We previously showed that MAFbx mediates MyoD...

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Identifiers

PMID: 19319192
DOI: 10.1371/journal.pone.0004973
PMCID: PMC2656614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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