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Article

Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.

Journal of cellular biochemistry - 1 May 2011

Olguín Hugo C, Patzlaff Natalie E, Olwin Bradley B

Abstract excerpt

Alveolar rhabdomyosarcoma (ARMS) are characterized by the expression of chimeric transcription factors Pax3-FKHR and Pax7-FKHR, due to chromosomal translocations fusing PAX3 or PAX7 with the FKHR gene. Although ARMS exhibits a muscle lineage phenotype, the cells evade terminal differentiation despite expressing the potent myogenic transcriptional regulator MyoD. Here we show that while Pax7-FKHR inhibits...

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Share to Forkhead Box Protein O1
Share to Forkhead Transcription Factors
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle Development

Share to MyoD Protein

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Share to Oncogene Proteins, Fusion

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Source

Open in PubMed Open full text

Identifiers

PMID: 21321994
DOI: 10.1002/jcb.23057
PMCID: PMC3071457

Genes

PAX3
PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.PMID 21321994Read ↗

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