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Article

Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.

Molecular cell - 26 Oct 2007

Serra Carlo, Palacios Daniela, Mozzetta Chiara, Forcales Sonia V, Morantte Ianessa, Ripani Meri, Jones David R, Du Keyong, Jhala Ulupi S, Simone Cristiano, Puri Pier Lorenzo

Abstract excerpt

During muscle regeneration, the mechanism integrating environmental cues at the chromatin of muscle progenitors is unknown. We show that inflammation-activated MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components of the muscle transcriptosome. p38 alpha/beta kinases recruit the SWI/SNF chromatin-remodeling complex; AKT1 and 2...

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Identifiers

PMID: 17964260
DOI: 10.1016/j.molcel.2007.08.021
PMCID: PMC2693200

Genes

IGF1
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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