Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.

Stem cell reports - 9 Jun 2015

Kollu Swapna, Abou-Khalil Rana, Shen Carl, Brack Andrew S

Abstract excerpt

To ensure accurate genomic segregation, cells evolved the spindle assembly checkpoint (SAC), whose role in adult stem cells remains unknown. Inducible perturbation of a SAC kinase, Mps1, and its downstream effector, Mad2, in skeletal muscle stem cells shows the SAC to be critical for normal muscle growth, repair, and self-renewal of the stem cell pool. SAC-deficient muscle stem cells arrest in G1 phase of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p21
Share to G1 Phase Cell Cycle Checkpoints

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kinetochores

Share to Mad2 Proteins

Share to Myoblasts

Share to Nocodazole

Share to Satellite Cells, Skeletal Muscle

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 25960061
DOI: 10.1016/j.stemcr.2015.04.006
PMCID: PMC4471836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.PMID 25960061Read ↗

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and agingSemantic proximity Read ↗

Beyond the bulk: overview and novel insights into the dynamics of muscle satellite cells during muscle regenerationSemantic proximity Read ↗

Muscle Stem Cells: A Model System for Adult Stem Cell Biology.Semantic proximity Read ↗

A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite CellsSemantic proximity Read ↗

SAC-ing mitotic errors: how the spindle assembly checkpoint (SAC) plays defense against chromosome mis-segregation.Semantic proximity Read ↗

Characterization of cellular senescence in aging skeletal muscle.Semantic proximity Read ↗

Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression.Semantic proximity Read ↗

Ataxia Telangiectasia and Rad3-related protein (ATR) maintains cardiac tissue functionalitySemantic proximity Read ↗

The altered fate of aging satellite cells is determined by signaling and epigenetic changesSemantic proximity Read ↗

A pivotal contribution of proteostasis failure and mitochondrial dysfunction to chromosomal instability-induced microcephalySemantic proximity Read ↗

Deregulation of Chromosome Segregation and CancerSemantic proximity Read ↗

Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.