Article

DNA repair byproduct 8-oxoguanine base promotes myogenic differentiation via OGG1-mediated activation of RAS-MEK-MyoD signaling pathway

2022-03-24

Abstract excerpt

<title>Abstract</title> During exercise, muscle contraction increases the level of reactive oxygen species (ROS), which has been acknowledged as key signaling entities in muscle remodeling and to underlie the healthy adaptation of skeletal muscle. ROS inevitably endows damage to genomic DNA of the myofibers, and DNA damage ought to be repaired to ensure the integrity and fidelity of genetic materials; yet, how...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 18658d82-e20c-5d05-bb09-6f1ac35097ce
DOI: 10.21203/rs.3.rs-1473019/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA repair byproduct 8-oxoguanine base promotes myogenic differentiation via OGG1-mediated activation of RAS-MEK-MyoD signaling pathwayDOI 10.21203/rs.3.rs-1473019/v1Read

A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4.Semantic proximity Read

Role of Free Radicals and Antioxidant Signaling in Skeletal Muscle Health and PathologySemantic proximity Read

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repairSemantic proximity Read

Hydrogen Enhanced the Myogenic Differentiation of Adipose Mesenchymal Stem Cells Through P38 MAPK Signaling PathwaySemantic proximity Read

Mitochondrial Respiratory Chain Function is crucial for Muscle Toxicity in Facioscapulohumeral Muscular DystrophySemantic proximity Read

Cellular responses to H(2)O(2) and bleomycin-induced oxidative stress in L6C5 rat myoblasts.Semantic proximity Read

A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivoSemantic proximity Read

Development of the 12-Base Short Dimeric Myogenetic Oli-godeoxynucleotide That Induces Myogenic DifferentiationSemantic proximity Read

Dynamic Processing of a Common Oxidative DNA Lesion by the First Two Enzymes of the Base Excision Repair Pathway.Semantic proximity Read

Mitochondrial DNA shifting in older adults following resistance exercise trainingThis paper article is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.Semantic proximity Read

DNA damage-activated ABL-MyoD signaling contributes to DNA repair in skeletal myoblasts.Semantic proximity Read

The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymesSemantic proximity Read