Article
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
The Journal of antimicrobial chemotherapy - 1 Feb 2014
Nebenzahl-Guimaraes Hanna, Jacobson Karen R, Farhat Maha R, Murray Megan B
Abstract excerpt
BACKGROUND: Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics for drug-resistant tuberculosis. Studies that use direct genetic manipulation to identify the mutations that cause M. tuberculosis drug resistance are superior to associational studies in elucidating an...
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