Article
Effect of mutation and genetic background on drug resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Jun 2012
Fenner Lukas, Egger Matthias, Bodmer Thomas, Altpeter Ekkehardt, Zwahlen Marcel, Jaton Katia, Pfyffer Gaby E, Borrell Sonia, Dubuis Olivier, Bruderer Thomas, Siegrist Hans H, Furrer Hansjakob, Calmy Alexandra, Fehr Jan, Stalder Jesica Mazza, Ninet Béatrice, Böttger Erik C, Gagneux Sebastien
Abstract excerpt
Bacterial factors may contribute to the global emergence and spread of drug-resistant tuberculosis (TB). Only a few studies have reported on the interactions between different bacterial factors. We studied drug-resistant Mycobacterium tuberculosis isolates from a nationwide study conducted from 2000 to 2008 in Switzerland. We determined quantitative drug resistance levels of first-line drugs by using Bactec...
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