Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex.

Antimicrobial agents and chemotherapy - 18 Oct 2021

Vargas Roger, Freschi Luca, Spitaleri Andrea, Tahseen Sabira, Barilar Ivan, Niemann Stefan, Miotto Paolo, Cirillo Daniela Maria, Köser Claudio U, Farhat Maha R

Abstract excerpt

Antibiotic resistance among bacterial pathogens poses a major global health threat. Mycobacterium tuberculosis complex (MTBC) is estimated to have the highest resistance rates of any pathogen globally. Given the low growth rate and the need for a biosafety level 3 laboratory, the only realistic avenue to scale up drug susceptibility testing (DST) for this pathogen is to rely on genotypic techniques. This raises...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amikacin
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diarylquinolines

Share to Drug Resistance, Multiple, Bacterial

Share to Epistasis, Genetic

Share to Kanamycin

Share to Mycobacterium tuberculosis

Share to Tuberculosis, Multidrug-Resistant

Source

Open in PubMed Open full text

Identifiers

PMID: 34460306
DOI: 10.1128/AAC.01164-21
PMCID: PMC8522733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Epistasis in Amikacin, Kanamycin, Bedaquiline, and Clofazimine Resistance in Mycobacterium tuberculosis Complex.PMID 34460306Read ↗

The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in <i>Mycobacterium tuberculosis</i> complexSemantic proximity Read ↗

Molecular Mechanisms Underlying Antimicrobial Resistance in Mycobacteria.Semantic proximity Read ↗

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.Semantic proximity Read ↗

Evolution of Drug Resistance in Tuberculosis: Recent Progress and Implications for Diagnosis and TherapySemantic proximity Read ↗

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.Semantic proximity Read ↗

Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine ApproachSemantic proximity Read ↗

Intragenic Distribution of IS6110 in Clinical Mycobacterium tuberculosis Strains: Bioinformatic Evidence for Gene Disruption Leading to Underdiagnosed Antibiotic Resistance.Semantic proximity Read ↗

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.Semantic proximity Read ↗

Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Bedaquiline- and clofazimine- selected Mycobacterium tuberculosis mutants: further insights on resistance driven largely by Rv0678Semantic proximity Read ↗

Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysisSemantic proximity Read ↗

Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.