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Simultaneous Detection of Drug-resistant Mutations in Mycobacterium tuberculosis and Determining their Role through In Silico Docking.

Infectious disorders drug targets - 1 Jan 2021

Nachappa Somanna Ajjamada, Neelambike Sumana M, Sarikhani Ahmad, Ramachandra Nallur B

Abstract excerpt

A molecular method for diagnosis of drug-resistant Tuberculosis is Multiplex allele-specific PCR (MAS-PCR), which is more time-efficient, and its accuracy is studied using DNA sequencing. Also, understanding the role of mutations, when translated to protein, in causing resistance helps in better drug designing. AIM: To study MAS-PCR in the detection of drug resistance in comparison to DNA sequencing in...

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PMID: 32188396
DOI: 10.2174/1871526520666200318111140

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