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Article

Resistant mutants of Mycobacterium tuberculosis selected in vitro do not reflect the in vivo mechanism of isoniazid resistance.

The Journal of antimicrobial chemotherapy - 1 Sept 2009

Bergval Indra L, Schuitema Anja R J, Klatser Paul R, Anthony Richard M

Abstract excerpt

OBJECTIVES: The high prevalence of isoniazid-resistant Mycobacterium tuberculosis is often explained by a high mutation rate for this trait, although detailed information to support this theory is absent. We studied the development of isoniazid resistance in vitro, making use of a laboratory strain of M. tuberculosis. METHODS: Spontaneous isoniazid-resistant mutants were characterized by molecular methods...

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Identifiers

PMID: 19578178
DOI: 10.1093/jac/dkp237
PMCID: PMC2724981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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