Article

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast

2024-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Human APOBEC single-strand (ss) specific DNA and RNA cytidine deaminases change cytosines to uracils and function in antiviral innate immunity, RNA editing, and can cause hypermutation in chromosomes. The resulting uracils can be directly replicated, resulting in C to T mutations, or uracil-DNA glycosylase can convert the uracils to abasic (AP) sites which are then fixed as C to T or C to G muta...

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Literature Corpus work: e5899af9-e217-5b8e-8c79-fa1bd610f7d2
DOI: 10.1101/2024.06.27.601081

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