Article
Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.
Cell reports - 26 Jan 2012
Ma Xin, Rogacheva Maria V, Nishant K T, Zanders Sarah, Bustamante Carlos D, Alani Eric
Abstract excerpt
Evolutionary theory assumes that mutations occur randomly in the genome; however, studies performed in a variety of organisms indicate the existence of context-dependent mutation biases. Sources of mutagenesis variation across large genomic contexts (e.g., hundreds of bases) have not been identified. Here, we use high-coverage whole-genome sequencing of a conditional mismatch repair mutant line of diploid yeast...
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