Article
Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen.
Science (New York, N.Y.) - 27 Sept 2013
Dejosez Marion, Ura Hiroki, Brandt Vicky L, Zwaka Thomas P
Abstract excerpt
Ensuring cooperation among formerly autonomous cells has been a central challenge in the evolution of multicellular organisms. One solution is monoclonality, but this option still leaves room for exploitative behavior, as it does not eliminate genetic and epigenetic variability. We therefore hypothesized that embryonic development must be protected by robust regulatory mechanisms that prevent aberrant clones from...
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