Article

A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state

2021-05-03

Abstract excerpt

Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements, and higher-order chromatin structures. Expectedly, these chromatin marks are indispensable for mammalian development and alterations often lead to diseases such as cancer. Molecularly, epigenetic mechanisms rely on factors to establish patterns, in...

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Literature Corpus work: cb7c68df-9f7e-5a1b-92bd-7588c4ab1c3b
DOI: 10.1101/2021.05.03.442415

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