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Article

p53-mediated hematopoietic stem and progenitor cell competition.

Cell stem cell - 2 Apr 2010

Bondar Tanya, Medzhitov Ruslan

Abstract excerpt

Cell competition was originally described in Drosophila as a process for selection of the fittest cells. It is likely to play an important role in tissue homeostasis in all metazoans, but little is known about its role and regulation in mammals. By using genetic mosaic mouse models and bone marrow chimeras, we describe here a form of cell competition that selects for the least damaged cells. This competition is...

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Identifiers

PMID: 20362536
DOI: 10.1016/j.stem.2010.03.002
PMCID: PMC2872065

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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