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Article

Secretory leukocyte protease inhibitor protein regulates the penetrance of frontotemporal lobar degeneration in progranulin mutation carriers.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Ghidoni Roberta, Flocco Rosa, Paterlini Anna, Glionna Michela, Caruana Loredana, Tonoli Elisa, Binetti Giuliano, Benussi Luisa

Abstract excerpt

The discovery that mutations in the gene encoding for progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases leading to dementia has brought renewed interest in progranulin and its functions in the central nervous system. Full length progranulin is preserved from cleavage by secretory leukocyte protease inhibitor (SLPI), one of the smallest serine protease inhibitor...

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Source

Identifiers

PMID: 24018267
DOI: 10.3233/JAD-131163

Genes

SLPI
GRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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