Article

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

2020-12-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> - Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-<italic>Pgrn</italic>). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are increasingly thought to contribute to FTLD-TDP-<italic>Pgrn</italic>...

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Literature Corpus work: 0a160fd6-8f00-545c-a2e1-07d1424b8d40
DOI: 10.21203/rs.3.rs-44128/v3

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