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Article

Serum biomarker for progranulin‐associated frontotemporal lobar degeneration

13 Mar 2009

Abstract excerpt

OBJECTIVE: Mutations that lead to a loss of progranulin (PGRN) explain a considerable portion of the occurrence of frontotemporal lobar degeneration. We tested a biomarker allowing rapid detection of a loss of PGRN. METHODS: We used an enzyme-linked immunosorbent assay to measure in serum the PGRN protein levels of six affected and eight unaffected carriers from within an extended Belgian founder family...

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PMID: 19288468
DOI: 10.1002/ana.21621

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