Article
Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration.
Neurology - 14 Oct 2008
Ghidoni R, Benussi L, Glionna M, Franzoni M, Binetti G
Abstract excerpt
BACKGROUND: Mutations in the progranulin gene (PGRN) were identified as the causal mechanism underlying frontotemporal lobar degeneration (FTLD). Most of these mutations are predicted to create null alleles leading to a 50% loss of progranulin transcript. METHODS: Patients underwent clinical and neurologic examination at the Memory Clinic of the IRCCS S. Giovanni di Dio-Fatebenefratelli, Brescia, Italy. We...
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