Progranulin in frontotemporal lobar degeneration and neuroinflammation.

Abstract excerpt

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency. Little is known about the normal function of PGRN in the central nervous system apart...

Topics

• Amino Acid Sequence
• Animals
• Brain
• Central Nervous System Diseases
• Dementia
• Humans
• Inflammation
• Intercellular Signaling Peptides and Proteins
• Microglia
• Molecular Sequence Data
• Mutation