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Article

Progranulin in frontotemporal lobar degeneration and neuroinflammation.

Journal of neuroinflammation - 11 Feb 2007

Ahmed Zeshan, Mackenzie Ian R A, Hutton Michael L, Dickson Dennis W

Abstract excerpt

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency. Little is known about the normal function of PGRN in the central nervous system apart...

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Identifiers

PMID: 17291356
DOI: 10.1186/1742-2094-4-7
PMCID: PMC1805428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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