Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.

doi:10.1016/j.neurobiolaging.2020.02.014

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Article

Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.

Neurobiology of aging - 1 Jul 2020

Sellami Leila, Rucheton Benoît, Ben Younes Imen, Camuzat Agnès, Saracino Dario, Rinaldi Daisy, Epelbaum Stephane, Azuar Carole, Levy Richard, Auriacombe Sophie, Hannequin Didier, Pariente Jérémie, Barbier Mathieu, Boutoleau-Bretonnière Claire, Couratier Philippe, Pasquier Florence, Deramecourt Vincent, Sauvée Mathilde, Sarazin Marie, Lagarde Julien, Roué-Jagot Carole, Forlani Sylvie, Jornea Ludmila, David Isabelle, LeGuern Eric, Dubois Bruno, Brice Alexis, Clot Fabienne, Lamari Foudil, Le Ber Isabelle

Abstract excerpt

GRN mutations are frequent causes of familial frontotemporal degeneration. Although there is no clear consensual threshold, plasma progranulin levels represent an efficient biomarker for predicting GRN mutations when decreased. We evaluated plasma levels to determine whether it could also predict age at onset, clinical phenotype, or disease progression in 160 GRN carriers. Importantly, progranulin levels were...

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PMID: 32171590
DOI: 10.1016/j.neurobiolaging.2020.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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