Article
Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study.
Neuro-degenerative diseases - 1 Jan 2012
Ghidoni Roberta, Stoppani Elena, Rossi Giacomina, Piccoli Elena, Albertini Valentina, Paterlini Anna, Glionna Michela, Pegoiani Eleonora, Agnati Luigi F, Fenoglio Chiara, Scarpini Elio, Galimberti Daniela, Morbin Michela, Tagliavini Fabrizio, Binetti Giuliano, Benussi Luisa
Abstract excerpt
BACKGROUND: Recently, attention was drawn to a role for progranulin in the central nervous system with the identification of mutations in the progranulin gene (GRN) as an important cause of frontotemporal lobar degeneration. GRN mutations are associated with a strong reduction of circulating progranulin and widely variable clinical phenotypes: thus, the dosage of plasma progranulin is a useful tool for a quick...
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