Article
Focused screening of a panel of cancer-related genetic polymorphisms reveals new susceptibility loci for pediatric acute lymphoblastic leukemia.
Pediatric blood & cancer - 1 Aug 2014
Offenmüller Sonja, Ravindranath Yadddanapudi, Goyette Gerard, Kanakapalli Deepa, Miller Kathryn S, Brecht Ines B, Zolk Oliver
Abstract excerpt
BACKGROUND: A genetic predisposition to acute lymphoblastic leukemia (ALL) in childhood is well established. Currently known risk loci, however, explain only one third of the estimated total risk related to common genetic variations. PROCEDURE: We genotyped 1,421 polymorphisms in 407 candidate genes from the SNP500Cancer database (National Cancer Institute) using the Illumina Cancer SNP Panel. We investigated 78...
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