Article
Molecular alterations of Ras-Raf-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt signaling pathways in colorectal cancers from a tertiary hospital at Kuala Lumpur, Malaysia.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Oct 2013
Yip Wai Kien, Choo Chee Wei, Leong Vincent Ching-Shian, Leong Pooi Pooi, Jabar Mohd Faisal, Seow Heng Fong
Abstract excerpt
Molecular alterations in KRAS, BRAF, PIK3CA, and PTEN have been implicated in designing targeted therapy for colorectal cancer (CRC). The present study aimed to determine the status of these molecular alterations in Malaysian CRCs as such data are not available in the literature. We investigated the mutations of KRAS, BRAF, and PTEN, the gene amplification of PIK3CA, and the protein expression of PTEN and...
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