The role of PIK3CA gene mutations in colorectal cancer and the selection of treatment strategies

Abstract excerpt

PIK3CA gene encodes the p110α catalytic subunit of PI3K, which regulates the PI3K/AKT/mTOR signaling pathway. PIK3CA gene mutation is one of the most common mutations in colorectal cancer (CRC), affecting about 15%-20% of CRC patients. PIK3CA gene mutation leads to the persistent activation of the PI3K/AKT/mTOR signaling pathway, which promotes the proliferation, invasion, metastasis, and drug resistance of CRC....

Topics

Join the communities discussing this publication.

• Advanced Breast Cancer Therapies
• Colorectal Cancer Treatments and Studies
• PI3K/AKT/mTOR signaling in cancer