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Article

KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer.

PloS one - 1 Jan 2012

Mao Chen, Zhou Junhua, Yang Zuyao, Huang Yafang, Wu Xinyin, Shen Hong, Tang Jinling, Chen Qing

Abstract excerpt

BACKGROUND: To investigate the frequency and relationship of the KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer (CRC). METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA was extracted from the formalin-fixed paraffin-embedded (FFPE) tissues of 69 patients with histologically confirmed CRC. Automated sequencing analysis was conducted to detect mutations in the...

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Identifiers

PMID: 22586484
DOI: 10.1371/journal.pone.0036653
PMCID: PMC3346734

Genes

BRAF
KRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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