PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.

doi:10.1158/1078-0432.CCR-12-3614

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Article

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2013

Day Fiona L, Jorissen Robert N, Lipton Lara, Mouradov Dmitri, Sakthianandeswaren Anuratha, Christie Michael, Li Shan, Tsui Cary, Tie Jeannie, Desai Jayesh, Xu Zheng-Zhou, Molloy Peter, Whitehall Vicki, Leggett Barbara A, Jones Ian T, McLaughlin Stephen, Ward Robyn L, Hawkins Nicholas J, Ruszkiewicz Andrew R, Moore James, Busam Dana, Zhao Qi, Strausberg Robert L, Gibbs Peter, Sieber Oliver M

Abstract excerpt

PURPOSE: PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated kinase inhibitors and anti-EGF receptor antibody therapy. Relationships between phosphoinositide 3-kinase (PI3K) pathway mutation, clinicopathologic characteristics, molecular features, and prognosis remain controversial. EXPERIMENTAL DESIGN: A total...

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Identifiers

PMID: 23633456
DOI: 10.1158/1078-0432.CCR-12-3614

Genes

PTEN
KRAS
BRAF
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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