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Article

Clinicopathological Associations of K-RAS and N-RAS Mutations in Indonesian Colorectal Cancer Cohort.

Journal of gastrointestinal cancer - 1 Jun 2018

Levi Michael, Prayogi Gintang, Sastranagara Farid, Sudianto Edi, Widjajahakim Grace, Gani Winiarti, Mahanadi Albert, Agnes Jocelyn, Khairunisa Bela Haifa, Utomo Ahmad R

Abstract excerpt

BACKGROUND: K-RAS and recently N-RAS gene mutation testing are mandatory requirements prior to anti-epidermal growth factor receptor (EGFR) monoclonal antibody treatment of metastatic CRC. Mutation prevalence and distribution in Indonesian colorectal cancer (CRC) are not known. METHODS: Combined methods of PCR high-resolution melt (HRM), restriction fragment length polymorphism (RFLP), and direct DNA sequencing...

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PMID: 28044264
DOI: 10.1007/s12029-016-9901-x

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EGFR

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