Article
Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.
Oncogene - 5 Jun 2008
Abubaker J, Bavi P, Al-Harbi S, Ibrahim M, Siraj A K, Al-Sanea N, Abduljabbar A, Ashari L H, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya K S
Abstract excerpt
Activation of the phosphatidylinositol 3'-kinase (PI3K)/AKT pathway results in an increase in cell proliferation and survival. Somatic mutations within the PI3K catalytic subunit, PIK3CA are common cause of increasing PI3K activity and are believed to be oncogenic in many cancer types. Few reports addressed the association between PIK3CA mutations and tumor progression specifically in microsatellite instable...
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