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Article

PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.

International journal of cancer - 15 Oct 2007

Kato Shunsuke, Iida Satoru, Higuchi Tetsuro, Ishikawa Toshiaki, Takagi Yoko, Yasuno Masamichi, Enomoto Masayuki, Uetake Hiroyuki, Sugihara Kenichi

Abstract excerpt

The PI3K-AKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival. Among the factors affecting the pathway, the K-Ras mutation and PIK3CA mutation are the most common oncogenic alterations in colorectal cancer. We hypothesized tha...

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Identifiers

PMID: 17590872
DOI: 10.1002/ijc.22890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17590872-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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