Article
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
International journal of cancer - 15 Oct 2007
Kato Shunsuke, Iida Satoru, Higuchi Tetsuro, Ishikawa Toshiaki, Takagi Yoko, Yasuno Masamichi, Enomoto Masayuki, Uetake Hiroyuki, Sugihara Kenichi
Abstract excerpt
The PI3K-AKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival. Among the factors affecting the pathway, the K-Ras mutation and PIK3CA mutation are the most common oncogenic alterations in colorectal cancer. We hypothesized that these two mutations are important in activation of the PI3K pathway and colorectal carcinogenesis. In this study, we...
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