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Article

Molecular validation of the schizophrenia spectrum.

Schizophrenia bulletin - 1 Jan 2014

Bigdeli T Bernard, Bacanu Silviu-Alin, Webb Bradley T, Walsh Dermot, O'Neill F Anthony, Fanous Ayman H, Riley Brien P, Kendler Kenneth S

Abstract excerpt

BACKGROUND: Early descriptive work and controlled family and adoption studies support the hypothesis that a range of personality and nonschizophrenic psychotic disorders aggregate in families of schizophrenic probands. Can we validate, using molecular polygene scores from genome-wide association studies (GWAS), this schizophrenia spectrum? METHODS: The predictive value of polygenic findings reported by the...

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PMID: 23970557
DOI: 10.1093/schbul/sbt122
PMCID: PMC3885304

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