APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease.

doi:10.1016/j.ajpath.2013.05.009

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Article

APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease.

The American journal of pathology - 1 Sept 2013

Yang Yue, Cudaback Eiron, Jorstad Nikolas L, Hemingway Jake F, Hagan Catherine E, Melief Erica J, Li Xianwu, Yoo Tom, Khademi Shawn B, Montine Kathleen S, Montine Thomas J, Keene C Dirk

Abstract excerpt

Apolipoprotein E4 (APOE4) genotype is the strongest genetic risk factor for late-onset Alzheimer disease and confers a proinflammatory, neurotoxic phenotype to microglia. Here, we tested the hypothesis that bone marrow cell APOE genotype modulates pathological progression in experimental Alzheimer disease. We performed bone marrow transplants (BMT) from green fluorescent protein-expressing human APOE3/3 or...

Topics

Alzheimer Disease
Amyloid beta-Peptides
Animals
Animals, Newborn
Apolipoprotein E3
Apolipoprotein E4
Behavior, Animal
Bone Marrow Transplantation
Cells, Cultured
Chimera

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Models, Animal

Green Fluorescent Proteins

Habituation, Psychophysiologic

Hematopoiesis

Hippocampus

Humans

Immunity, Innate

Immunomodulation

Source

Open in PubMed Open full text

Identifiers

PMID: 23831297
DOI: 10.1016/j.ajpath.2013.05.009
PMCID: PMC3763765

Genes

APOE
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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