Article
Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Apr 1998
Sheng H, Laskowitz D T, Bennett E, Schmechel D E, Bart R D, Saunders A M, Pearlstein R D, Roses A D, Warner D S
Abstract excerpt
Apolipoprotein E (apoE), a 34-KD glycosylated lipid-binding protein, is expressed as three common isoforms in humans (E2, E3, or E4). Clinical evidence suggests that the apoE genotype (APOE) may be a risk factor for poor outcome after acute central nervous system injury. This was examined further in transgenic mice constructed with the human APOE3 or APOE4 gene under the control of human promoter and tissue...
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