Article
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.
The Journal of biological chemistry - 5 Dec 2003
Lynch John R, Tang Wen, Wang Haichen, Vitek Michael P, Bennett Ellen R, Sullivan Patrick M, Warner David S, Laskowitz Daniel T
Abstract excerpt
Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein E plays an important role in modifying systemic and brain inflammatory responses, there is little data investigating apoE isoform-specific effects in vivo. In this study, we compared the inflammatory responses of targeted-replacement mice...
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