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Article

Increased vulnerability to focal ischemic brain injury in human apolipoprotein E4 knock-in mice.

Journal of neuropathology and experimental neurology - 1 Mar 2003

Mori Takashi, Kobayashi Mariko, Town Terrence, Fujita Shinobu C, Asano Takao

Abstract excerpt

Accumulating evidence suggests that among the 3 human apolipoprotein E (apoE) isoforms encoded by the human APOE gene, the e4 allele may act to exacerbate brain damage in humans and animals. This study aimed to compare the isoform-specific vulnerability conferred by human apoE to ischemic brain damage, using mice expressing human apoE isoforms (apoE2, apoE3, or apoE4) in place of mouse apoE, produced by the...

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Source

Identifiers

PMID: 12638732
DOI: 10.1093/jnen/62.3.280

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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