Article
Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus.
The Journal of infectious diseases - 1 Feb 2014
Aka Peter V, Kuniholm Mark H, Pfeiffer Ruth M, Wang Alan S, Tang Wei, Chen Sabrina, Astemborski Jacquie, Plankey Michael, Villacres Maria C, Peters Marion G, Desai Seema, Seaberg Eric C, Edlin Brian R, Strickler Howard D, Thomas David L, Prokunina-Olsson Ludmila, Sharp Gerald B, O'Brien Thomas R
Abstract excerpt
Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti-hepatitis C virus (HCV)-positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10(-5)) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent)....
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