IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection.

doi:10.1016/j.meegid.2016.01.020

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Article

IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2016

Wu Ruihong, Chi Xiumei, Wang Xiaomei, Sun Haibo, Lv Juan, Gao Xiuzhu, Yu Ge, Kong Fei, Xu Hongqin, Hua Rui, Jiang Jing, Sun Bing, Zhong Jin, Pan Yu, Niu Junqi

Abstract excerpt

Recently, the dinucleotide variant ss469415590 (TT/ΔG) in a novel gene, interferon lambda 4 (IFNL4), was identified as a stronger predictor of hepatitis C virus (HCV) clearance in individuals of African ancestry compared with rs12979860. We aimed to determine whether this variant contributes to treatment decisions in a Chinese population. A total of 447 chronic hepatitis C (CHC) patients (including 328 treated...

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PMID: 26820907
DOI: 10.1016/j.meegid.2016.01.020

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