Article
Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.
Journal of hepatology - 1 Nov 2015
O'Brien Thomas R, Pfeiffer Ruth M, Paquin Ashley, Lang Kuhs Krystle A, Chen Sabrina, Bonkovsky Herbert L, Edlin Brian R, Howell Charles D, Kirk Gregory D, Kuniholm Mark H, Morgan Timothy R, Strickler Howard D, Thomas David L, Prokunina-Olsson Ludmila
Abstract excerpt
BACKGROUND & AIMS: Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant'). An IFNL3 3' untranslated region polymorphism (rs4803217) has been proposed as a causal...
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