IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection.

doi:10.1097/QAD.0000000000000773

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection.

AIDS (London, England) - 10 Sept 2015

Real Luis M, Herrero Rocío, Rivero-Juárez Antonio, Camacho Ángela, Macías Juan, Vic Sandra, Soriano Vincent, Viedma Sergio, Guardiola Josep M, Fibla Joan, Rivero Antonio, Pineda Juan A, Caruz Antonio

Abstract excerpt

The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CCR5 gene

Share to Hepatitis C

Share to Hepatitis C virus research

Share to HIV-1

Share to HIV Infections

Share to Interleukins

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 26372394
DOI: 10.1097/QAD.0000000000000773

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection.PMID 26372394Read ↗

Targeted next-generation sequencing approach for CCR5, CXCR4 and IFNAR1 genes in HIV+ participants: Association of single nucleotide polymorphisms with CD4+ T cell count and HIV replication in patients receiving antiretroviral therapySemantic proximity Read ↗

IFN-stimulated gene expression is independent of the IFNL4 genotype in chronic HIV-1 infection.Semantic proximity Read ↗

IFNL4 genotype influences the rate of HIV-1 seroconversion in men who have sex with men.Semantic proximity Read ↗

Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C.Semantic proximity Read ↗

IFNL4: Notable variants and associated phenotypes.Semantic proximity Read ↗

The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection.Semantic proximity Read ↗

No Association of IFNL4 Genotype With Opportunistic Infections and Cancers Among Men With Human Immunodeficiency Virus 1 Infection.Semantic proximity Read ↗

Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.Semantic proximity Read ↗

Genetic polymorphism in IFNL4 and response to pegylated interferon-α and ribavirin in Japanese chronic hepatitis C patients.Semantic proximity Read ↗

Innate and adaptive genetic pathways in HCV infection.Semantic proximity Read ↗

Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.Semantic proximity Read ↗

Comparison of functional variants in IFNL4 and IFNL3 for association with HCV clearance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.