Article
Genetic variants at the IFNL3 locus and their association with hepatitis C virus infections reveal novel insights into host-virus interactions.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jul 2014
Chinnaswamy Sreedhar
Abstract excerpt
Human genetic variation plays a critical role in both spontaneous clearance of and response to interferon (IFN)-based therapies against hepatitis C virus (HCV) as shown by the success of recent genome-wide association studies (GWAS). Several GWAS and later validation studies have shown that single nucleotide polymorphisms (SNPs) at the IFNL3 (formerly IL28B) locus on chromosome 19 are involved in eliminating HCV...
Topics
- Genetic Variation
- Hepacivirus
- Hepatitis C, Chronic
- Host-Pathogen Interactions
- Humans
- Interferons
- Interleukins
- Polymorphism, Single Nucleotide
- Treatment Outcome