Article
Polymorphisms near the IFNL3 Gene Associated with HCV RNA Spontaneous Clearance and Hepatocellular Carcinoma Risk.
Scientific reports - 25 Nov 2015
Lee Mei-Hsuan, Yang Hwai-I, Lu Sheng-Nan, Lin Yu-Ju, Jen Chin-Lan, Wong Kang-Hsuan, Chan Soa-Yu, Chen Liang-Chun, Wang Li-Yu, L'Italien Gilbert, Yuan Yong, Chen Chien-Jen
Abstract excerpt
The aims of this study were to investigate associations between single nucleotide polymorphisms (SNPs) near the genes IFNL2, IFNL3, and IFNL4 and spontaneous clearance of hepatitis C virus (HCV) and to evaluate variants for their risk of hepatocellular carcinoma (HCC) among subjects in whom spontaneous HCV RNA clearance did not occur. In the first study, 889 untreated anti-HCV-seropositive patients without HCC...
Topics
- Adult
- Alleles
- Carcinoma, Hepatocellular
- Case-Control Studies
- Female
- Genotype
- Hepacivirus
- Humans
- Interferons
- Interleukins
- Linkage Disequilibrium