Article
Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Nov 2014
Knevel Rachel, Klein Kerstin, Somers Klaartje, Ospelt Caroline, Houwing-Duistermaat Jeanine J, van Nies Jessica A B, de Rooy Diederik P C, de Bock Laura, Kurreeman Fina A S, Schonkeren Joris, Stoeken-Rijsbergen Gerrie, Helmer Quinta, van der Linden Michael P M, Kern Marlena, Manjarrez-Orduno Nataly, Rodriguez-Rodriquez Luis, Stinissen Piet, Huizinga Tom W J, Toes Rene E M, Gay Steffen, Gregersen Peter K, Somers Veerle, van der Helm-van Mil Annette H M
Abstract excerpt
BACKGROUND: Joint destruction is a hallmark of autoantibody-positive rheumatoid arthritis (RA), though the severity is highly variable between patients. The processes underlying these interindividual differences are incompletely understood. METHODS: We performed a genome-wide association study on the radiological progression rate in 384 autoantibody-positive patients with RA. In stage-II 1557 X-rays of 301 Dutch...
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