Article
SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Oct 2014
Juge Pierre-Antoine, van Steenbergen Hanna W, Constantin Arnaud, Tobon Gabriel J, Schaeverbeke Thierry, Gazal Steven, Combe Bernard, Devauchelle-Pensec Valérie, Nigon Delphine, van der Helm-van Mil Annette H M, Dieude Philippe
Abstract excerpt
OBJECTIVE: We recently reported an association of the SPP1 rs9138 and rs11439060 functional variants with the risk of rheumatoid arthritis (RA), the association being greater in anti-citrullinated protein autoantibody (ACPA)-negative patients. We hypothesised that SPP1 may contribute to the severity of joint destruction in RA, specifically in the ACPA-negative population. METHODS: Patients with RA in the ESPOIR...
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